49ers vs. Cardinals injury report: Deebo out; Kittle questionable

SANTA CLARA: The 49ers are gearing up for their last game of the season, but they’ll be without some key players. Deebo Samuel is out due to a wrist and rib injury he picked up in the last game against the Lions. He won’t be the only one watching from the sidelines; Brock Purdy is also out with an elbow issue.

On the offensive line, Spencer Burford is missing another game with a calf injury. Colton McKivitz is questionable but seems ready to go after missing a couple of practices. George Kittle is also listed as questionable, and he might have to step in to help the offensive line, which is a bit inexperienced right now.

Defensively, the 49ers will miss cornerback Deommodore Lenoir and defensive lineman Robert Beal. The good news is that Nick Bosa is only questionable and plans to play. Even though this game doesn’t matter for playoff standings, players like Bosa and Fred Warner are eager to finish strong.

Warner said, “Let’s start the year 1-0, 2025,” emphasizing the importance of ending the season on a high note. The 49ers had a tough season, dealing with injuries to several starters, including Christian McCaffrey and Brandon Aiyuk.

Here’s the full injury report for the game:
49ers:
OUT: OL Spencer Burford, QB Brock Purdy, CB Deommodore Lenoir, WR Deebo Samuel, DL Robert Beal
QUESTIONABLE: TE George Kittle, S Ji’Ayir Brown, OL Colton McKivitz, CB Isaac Yiadom

Cardinals:
OUT: K Matt Prater
QUESTIONABLE: CB Sean Murphy-Bunting, LB Mack Wilson, OT Jackson Barton, WR Michael Wilson